A study discovered that one dose of psilocybin, the main ingredient in the psychedelic class A drug “magic mushrooms,” has a long-lasting and significant effect in treating cases of depression that are resistant to other medications.
A peer-reviewed, mid-stage trial published in the New England Journal of Medicine indicated that a single 25mg dose of the drug, combined with psychotherapy support, “significantly” reduced depressive symptoms in patients who did not react to other medications.
Researchers stated that the study, led by UK-based pharmaceutical company Compass Pathways, was the largest to date on the use of psilocybin as a depression treatment and that its findings paved the road for regulatory approval.
The use of psychedelics to treat mental illnesses has been heavily contested. Global regulators currently approve a relatively restricted number for medical purposes.
However, in recent years, more firms have begun to investigate various psychedelic-based treatments for mental health disorders. The study is a step toward regulating them for medical use.
Ketamine is sometimes used “off-label” for treatment-resistant depression, but esketamine, a similar molecule, is approved as a nasal spray in the UK and the United States.
Micro-dosing, or ingesting small amounts of psychedelics, has also been found to be beneficial, though researchers believe further research is needed to determine its benefits.
According to James Rucker, a senior lecturer at King’s College London and an author of the NEJM paper, the lack of effective medicines available to those with treatment-resistant depression could “seriously impact on patients and the people around them”.
“Treatment alternatives are frequently restricted, with undesirable side effects and/or stigma. As a result, new treatment paradigms are required, and clinical research into novel treatments is essential.”
The study was carried out at 22 international sites, including King’s College London and the South London and Maudsley NHS Foundation Trust, which specializes in mental health.
If you are searching for “how long do magic mushrooms last” it can be reserved up to the morning or 2 – 3 days depending upon which type of magic mushroom you ate. Eating a lot of Psychoactive Mushrooms lasts up to 3 days, so be careful about the quantity.
The trial included 233 patients with treatment-resistant depression who were given 1mg, 10mg, or 25mg of psilocybin each. Those in the first group served as a control group, and neither the researchers nor the patients knew what level of dose the latter received.
Patients were monitored for 12 weeks, with their symptoms assessed the day before injection and at regular intervals thereafter.
According to the study discovered that the medicine permitted “powerful emotional breakthroughs” for patients and helped them acquire “a sense of connection to themselves”.
Side effects of psilocybin included headaches, nausea, dizziness, exhaustion, and suicidal ideation in all dose groups.
According to the researchers, only one patient had a “bad trip” that was treated with sedatives. The hallucinogenic portion of the event lasted several hours and was conducted under observation, following which patients were free to go about their business.
The chemical, known as COMP360, has received breakthrough classification from UK and US regulators, which might assist in accelerating the research and commercialization of new treatments. Compass is also testing it on patients with post-traumatic stress disorder and anorexia nervosa.
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